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KMID : 0604520120380040311
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Journal of the Society of Cosmetic Scientists of Korea
2012 Volume.38 No. 4 p.311 ~ p.319
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The Study about Relief Effect of Essential Oil on Seborrheic Dermatitis with Co-culture System
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Kim Ah-Reum
Kim Su-Na
Lee Hyun-Gee
Jeon Byeong-Bae
Park Won-Seok
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Abstract
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Seborrheic dermatitis (SD) is the skin disease occurred because of Malassezia yeast which grows on the skin and scalp, and this yeast lives on sebum lipid, and their metabolite, free lipid acids are thought to be the main irritant on skin. To find out effective cosmeceutical ingredients to treat SD symptoms, we established novel cell-based in vitro model mimicking SD symptoms. This in vitro model adopted the co-culture system with primary sebocyte & HaCaT keratinocyte. We used M. globosa yeast extract, arachidonic acid, linoleic acid and dihydrotestosterone as SD inducers. In the co-culture system with optimized concentrations for SD-inducing cocktail, the production of IL-8 and sebum lipids increased up to 2-fold, and then we screened with commercial essential oils by monitoring IL-8 as a key inflammatory biomarker. Then we found that Cinnamomum zeylanicum oil, Mentha arvensis oil effectively down-regulated IL-1α, IL-6, IL-8 cytokines which over-produced by SD-inducing cocktail. Additionally, two essential oils also showed inhibitory effect on sebum lipid synthesis from primary sebocyte and growth inhibitory effect to M. globosa yeast (MICs were lower than 0.0625 %). Our recent results suggest that Cinnamomum zeylanicum oil and Mentha arvensis oil could be effective natural herbal remedies to relieve or protect scalp seborrheic dermatitis.
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KEYWORD
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Seborrheic dermatitis, co-culture system, M. globosa, Cinnamomum zeylanicum oil, Mentha arvensis oil
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